The cast of "Alexander and the Terrible, Horrible, No Good, Very Bad Road Trip," including Eva Longoria, Jesse Garcia, Paulina Chávez, Rose Portillo, Thom Nemer, Cheech Marin, Cristo Fernández, Harvey Guillén, and Mabel Cadena joined director Marvin Lemus, writer Matt Lopez and producers Dan Levine and Lisa Henson at the El Capitan Theatre in Hollywood for the film's premiere. The all-new family comedy will stream exclusively on Disney+ beginning March 28, 2025.

As part of Disney's commitment to supporting both immediate relief and long-term recovery efforts following the wildfires in Los Angeles County, impacted children and families from Boys & Girls Club of the Foothills and Burbank and Greater East Valley chapters were in attendance as well.